Nucleoside chemistry - full of unknowns and possibilities.

Nucleoside chemistry is one of the cornerstones of the popular nucleic acid drugs in recent years. Nucleoside derivatives are widely used as anti-tumor and antiviral small molecule drugs, and are also the basic building blocks and synthetic raw materials of nucleic acid drugs. Meanwhile, nucleoside derivatives are also important raw materials for gene sequencing kits. Nucleic acid drugs have a much larger number of targets than small molecules and a longer half-life, which will transform many diseases from incurable to treatable, from short-term to long-term, and ultra long-term effects; Moreover, nucleic acid drugs have the advantage of digital design, and their research and development speed far exceeds that of small molecule and antibody drugs. The successful commercialization of mRNA and small nucleic acid drugs has propelled the entire industry to the early stages of the outbreak.

Hefei StongBio technology has a professional production and research and development team, with a core technical team with over 10 years of work experience in the field of nucleotides and nucleotides. With excellent R&D and industrialization capabilities, we provide customers with products and customized services in multiple fields such as modified nucleotides, nucleotides, phosphamide monomers, fluorescence and chemiluminescent dyes. The modification of nucleoside bases or sugar rings is a commonly used strategy to enhance the pharmacokinetic and pharmacological properties of nucleoside molecules, reduce the immunogenicity of nucleic acid drugs, and enhance stability. A series of conventional and unconventional natural nucleoside compounds modification methods have been successfully developed, including the modification of the sugar ring and base, the modification of the glycosidic bond and the stereo and enantiomer selective reaction, which can rapidly and efficiently synthesize modified nucleoside compounds and their derivatives, and can meet the needs of nucleoside nucleic acid drugs from early research and development to preclinical development.

In recent years, the nucleoside and nucleic acid chemistry industry in China has flourished, and the demand for technology and talent is very urgent. Driven by nucleic acid chemistry and molecular biology technology, Shitong Biotechnology is committed to the development and industrial application of core raw materials for gene diagnosis and treatment reagents, small nucleic acid drugs, DNA&RNA synthesis, mRNA vaccines, and other products. Contribute to China's nucleoside chemistry!