Locked nucleic acid Series (LNA)

Locked nucleic acid (LNA) is a special bicyclic nucleotide derivative, which contains one or more 2 '- O, 4' - C-methylene- β- D-furan ribonucleic acid monomer, the 2 '- O and 4' - C positions in the ribose undergo different condensation reactions to form an oxygen methylene bridge, a sulfur methylene bridge, or an amine methylene bridge, and are connected into a ring. This ring bridge locks in the N configuration of the C3 '- endotype of the furan, reducing the flexibility of the ribose structure and increasing the stability of the phosphate skeleton local structure.

LNA is one of the latest RNA analogues. Due to its unique properties, compared with unmodified nucleic acids, LNA shows stronger binding affinity, sequence specificity, thermal stability and nuclease resistance.

LNA can be used for molecular diagnosis and provide accurate and rapid mutation detection, thereby improving specificity and sensitivity; LNA can also be used as a safe and effective antisense drug for the treatment of diseases such as cancer and viruses by controlling gene expression.